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And that belief seems to shape how people are judged. What Happens When Weight Returns The researchers also examined what happens when people stop using GLP-1 medications

In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

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In 2023, the FDA approved tirzepatide for chronic weight management for adults with obesity