Patient Educ Couns 99(6):926943
Lilly touted the new pill as the only oral GLP-1 that can be taken without restrictions on eating and drinking (manufacturers tell patients taking Wegovy to wait 30 minutes before eating, drinking or taking another medication)
However, people with a BMI of 27 or higher may also qualify if they have weight-related health conditions, such as type 2 diabetes or hypertension
371 In a study examining the effects of GLP-1RA on osteoporosis induced by ovariectomy in aged rats, administering exendin-4 for 16 weeks prevented deterioration of the trabecular microarchitecture and increased bone strength

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In a clinical study involving patients with type 2 diabetes, an almond-based diet with a low-carbohydrate content, which had been previously shown to possess marked prebiotic properties [110, 111], resulted in augmentation of the number of SCFA-producing bacteria species, such as Roseburia , Ruminococcus and Eubacterium , which led to an increase in fasting blood GLP-1 levels and also promoted antidepressive effects after three months [112]