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For individuals with Type 2 diabetes, who are at an increased risk for heart disease, GLP-1 therapy has been shown to lower the risk of heart attack, stroke, and other cardiovascular events

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Furthermore, hyperhomocysteinemia increases the risk of an ischemic stroke by inhibiting the endogenous anticoagulant system and increasing thrombin production (Faverzani et al

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Many promising effective strategies have been developed to design safer metal-based NPs for further biomedical applications to minimize NP toxicity