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Farah C, Michel LYM, Balligand JL

Both medications share a similar side effect profile because both activate the GLP-1 receptor

In particular, increased plasma insulin concentrations stimulate the gonadotropin releasing hormone (GnRH) pulsatility and potentiate the LH-dependent effect on the ovarian theca cells, leading to the enhanced synthesis of androgens and to the arrest of pre-antral follicle development [13]

If symptoms persist or dietary intake becomes significantly restricted, ask your GP or trial team for a referral to a registered dietitian

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis