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2.4 Starting Dose in Pediatric and Adult Patients with Either Type 1 or Type 2 Diabetes Already on Insulin Therapy Dosage adjustments are recommended to lower the risk of hypoglycemia when switching patients to TOUJEO from another insulin therapy [see Warnings and Precautions (5.3)]

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This is often the first benefit users notice and is a major contributor to improved daytime energy

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A double-blind, randomized, placebo-controlled trial demonstrated that perioperative high-dose intravenous injection of Gln (0.5 g/kg/day, P.O for 3 days) raised plasma Gln concentrations and maintained plasma GSH levels in postoperative patients undergoing cardiopulmonary bypass (CPB) [113]

Abbreviations ASCVD: Atherosclerotic cardiovascular disease GLP-1: Glucagon-like peptide-1 SGLT2: Sodium-glucose cotransporter 2 References American Diabetes Association Professional Practice Committee (2024) 9