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A patient with metabolic syndrome may need 2+ years of semaglutide to stabilize metabolism and prevent disease progression, while another patient focused on cosmetic weight loss might achieve their goal in 12-18 months and then transition to maintenance therapy at lower doses

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For these reasons, GLP-1 analogues have been FDA-approved for treatment of obesity and diabetes, Dr

Exp Mol Med 53 , 15801591 (2021)