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In the MASLD (metabolic dysfunction-associated steatotic liver disease) substudy, participants on the 12 mg dose achieved greater than 85% liver fat normalization

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However, completely shutting off your stomach acid while food is sitting in a slow-moving stomach stops it from digesting properly

These are the trials the FDA will scrutinize most closely

Some of the most common or potential side effects include: Nausea Constipation Vomiting Diarrhea Abdominal Pain Headache Indigestion Injection site reactions Dizziness Back pain Increased Lipase or Amylase Altered taste Nasopharyngitis (common cold) Passing Gas Bloating Belching Gastroenteritis Decreased appetite Fatigue Gastroesophageal reflux disease Low blood sugar (hypoglycemia) in those with Type 2 diabetes Upset stomach These symptoms often subside as your body adjusts to the medications

On the other hand, this selection bias should theoretically support higher initiation rates and persistence