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Adaptive responses, such as endothelial cell proliferation, cytoskeletal reorientation, renin-angiotensin-aldosterone system (RAAS) activation, and the production of vascular permeability factors, TGF-, and fibronectin are triggered in an attempt to compensate for these changes [30]

CC: Conceptualization, Investigation, Supervision, Writing original draft, Writing review & editing

The effects of aging on CRH regulation and whether CRH influences the course of aging are still unclear

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Myocardial substrate optimization

We also believe that stricter fasting guidelines are unlikely to be beneficial nor reasonable, as illustrated by this case of regurgitation even with a prolonged fasting period