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First, in vitro studies predominantly use immortalized cell lines (e.g., HepG2, L02) or primary hepatocytes under simplified lipid overload conditions, failing to recapitulate the complex in vivo microenvironment of NAFLDincluding crosstalk between hepatocytes, hepatic stellate cells, and immune cells, or systemic metabolic dysregulation

Cost and availability of healthy foods are two reasons

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Improved nutrient delivery

Some experience mild acid reflux or changes in bowel habits

A leaky gut can result in the absorption of potentially problematic substances and lead to impaired detox abilities