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A large case-control observational study of 58,769 patients diagnosed with dementia and 225,574 matched controls found statistically significant associations of dementia risk with exposure to anticholinergic medications, such as antidepressants, antipsychotics, antiparkinsonians, antiepileptics, and bladder anticholinergics

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If you compare it to other supplements like caffeine, beta alanine, or creatine, Citrulline Malate is probably less popular

Here's the general trajectory

Additionally, aged garlic extract at doses of 2.4 to 7.2 g/day resulted in short-term reductions in ex vivo platelet aggregation (144) and reductions in serum cholesterol concentrations up to 12 weeks (16)

Please see Prescribing Information and Medication Guide for RYBELSUS