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Among these, PYY, a hormone secreted by intestinal L cells, circulates in two principal bioactive forms: PYY(1-36) and PYY(3-36), which exhibit distinct receptor affinities and physiological roles ( 2 Biological properties of PYY 2.1 Synthetic secretion and biological expression of PYY PYY was first isolated and named in 1980 from the small intestine of pigs, with its name derived from its molecular feature of having tyrosine at both the N-terminus and C-terminus ( In adult mammals, PYY expression is primarily confined to endocrine cells within the gastrointestinal tract