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Indeed, pretreatment with VE has been demonstrated in various experimental models to significantly reduce the generation of oxygen and nitrogen free radicals induced by seizures, with effects observable within a time frame of minutes to hours [53, 113]

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51, 35 10.1186/s40659-018-0184-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 74.Costantini A., Pala M.I., Grossi E., Mondonico S., Cardelli L.E., Jenner C.et al