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Indeed, previous work has found that linagliptin protects human isolated islets from glucose-, lipid- and cytokine-induced toxicity [30]

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The combination of a RAAS inhibitor with a steroidal MRA (spironolactone or eplerenone) may not be suitable, despite steroidal MRAs demonstrating efficacy in conditions such as HFrEF, resistant hypertension [58,59,60,61], hyperaldosteronism (spironolactone), as well as reducing proteinuria/albuminuria [60,61,62,63]

Erecinska, M