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Treatment with anti-somatostatin antibodies or co-infusion with a somatostatin receptor 2 antagonist eliminated the GLP- 1-mediated suppression of glucagon secretion [71]

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Eli Lilly is also developing oral GLP-1 receptor agonists, including compounds such as orforglipron, which have shown significant weight loss and glycemic improvements in Phase III clinical trials

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Ye Z, Chen H, Ji S, Hu Y, Lou X, Zhang W, et al