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10.1172/jci107797 J

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It also activates reward-related brain regions that respond to food, making food generally less appealing

Adults with a BMI of 30 kg/m or higher-or at least 27 kg/m with weight-related comorbidities-who have not succeeded with lifestyle changes alone and who do not have contraindications such as heart disease, uncontrolled hypertension, glaucoma, hyperthyroidism, pregnancy, or a history of drug abuse

Payers dont expect other chronic disease medications to lower total health care costs