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Vitamin B-12 is a crucial nutrient that plays a pivotal role in several vital bodily functions

Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

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Similarly, punicalagin promotes nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, which boosts antioxidant defenses while decreasing apoptosis and inflammation (Al-Khawalde et al