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However, these results appear to be more significant when supplementation is combined with a diet and exercise program

doi: 10.7759/cureus.11308 9 VeenstraCMKraussJC

It is especially recommended when excess weight is associated T2D, polycystic ovary syndrome, MASH, CVD, hypogonadism, musculoskeletal limitations, or as a preoperative intervention before bariatric surgery, and for weight regain after surgery [129]

10.1006/taap.1994.1076 142 SongJ

Suleiman MS, Halestrap AP, Griffiths EJ