And as we age, the hypothalamuss thermoregulatory work becomes less stable, meaning the body gets its temperature signaling wrong more frequently, setting off more of that sweaty, sheet-drenching discomfort
As the popularity of GLP-1 receptor agonists like Ozempic, Wegovy, and Mounjaro continues to surge, so do concerns about their safety
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We employ variants of the peptides GLP-1 and exendin-4 to explore the interplay between helical propensity near the agonist N-terminus and the ability to bind to and activate the receptor
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The olfactory mucosa provides a pathway that partially bypasses the blood-brain barrier, delivering peptides to the central nervous system more efficiently than peripheral routes
