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Unlike setmelanotide, which can activate melanocortin receptors MC3R and MC1R in addition to MC4R 36 , RM-718 by design, avoids stimulating MC1R 40 and thereby avoids the common hyperpigmentation adverse event 41 that can arise when MC1R is stimulated 42

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A medically responsible conversation should separate three categories: what has been observed in cells, what has been observed in animals, and what has been proven in humans

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Thats why timely diagnosis and treatment are essential