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But discontinuation studies show significant weight regain in most patients who stop the medication

Comorbidities: Documentation of weight-related health conditions (high blood pressure, high cholesterol, sleep apnea, cardiovascular disease) that support the need for additional treatment

In the INSPIRE cohort of 106 patients with advanced solid tumors treated with pembrolizumab (anti-PD-1 antibody) (NCT03702309) (235), higher serum choline levels were associated with augmented CD8 - T cells and B cells in the tumor stroma, as well as an elevated CD3 + CD8 + cytotoxic T cells to CD3 + CD8 - FOXP3 + T regulatory cells ratio in the tumors (235)

Most providers consider staying at the lowest dose that produces adequate weight loss as the ideal strategy for long-term treatment sustainability