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The treatment must be an add-on therapy to optimal standard treatment, which must include, unless contraindicated or cannot be tolerated, a beta blocker and angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker or angiotensin receptor-neprilysin inhibitor

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The question is whether these specific ingredients, at the doses provided in Activate, actually trigger meaningful AMPK activation in humans

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Even at lower doses, tirzepatide can reduce HbA1c more than the highest doses of semaglutide