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In the survodutide arm (a GLP-1 and glucagon receptor dual agonist), liver mass dropped 55% while muscle loss in the casted leg was comparable across semaglutide, survodutide, and pair-fed controls

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[2] [3] [4] In addition to its efficacy in epilepsy and migraine prophylaxis, topiramate has also demonstrated neuroprotective effects against hypoxic-ischemic brain damage in both in vitro and animal models

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