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GLP-1 mimics the natural gut hormone glucagon-like peptide-1, which stimulates insulin release, slows digestion, and signals the brain when the stomach is full

However, in one case with prior history of RYGB postmeal insulin clearance measured during oral meal ingestion, condition bypassing the foregut, was lower than that during feeding through a gastrostomy tube, setting that includes the foregut, despite similar GLP-1 and GIP secretion [27]

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Common adverse effects include nausea, vomiting, diarrhoea, injection site reactions, and increased heart rate, particularly during dose escalation

In the Nurses Health Study II [14], increases in BMI were linked to a progressive increase in the risk of developing psoriasis

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