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Cardiovascular safety monitoring was standard per protocolno signals beyond expected GLP-1 class effects

Rare cases of anosmia (loss of smell) have been linked to specific nasal sprays contaminated with harmful ingredients

This is corroborated by setmelanotides clinical trials, where participants with monogenic obesity or HO respond more strongly to treatment than general obese participants (NCT02041195, NCT01749137) (75, 77, 79, 87, 9094)

This is actually one argument in favor of microdosing , where gastrointestinal effects are minimized while anti-inflammatory receptor activation may still occur

Feel more confident as they work toward their health goals

These individuals were randomized to either the placebo group or one of the monthly fixed-dose groups (placebo, 140 mg, 280 mg or 420 mg)