These changes of the a-loop conformation allow the substrate and ATP access, further increasing the intrinsic TK activity towards phosphorylation of other tyrosines in the receptor and subsequently of exogenous substrate proteins
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The latter ones are the main target of oxidative damage
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The authors assessed the gene expression of FGF-21 in myocardial tissue of obese rodents at baseline and after a 4-week treatment, and found that dapagliflozin treatment increases FGF-21 gene expression and reduces triglyceride content in myocardial tissue, indirectly suggesting that dapagliflozin promotes a browning effect [88]