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The pulsatile pattern is important because GH receptor sensitivity, downstream IGF-1 production, and metabolic effects all depend on the pulse amplitude and inter-pulse interval

References Minogue SC, Sun DA (2005)

[59] believe that the role of Prx2 as Hb chaperone is especially important in the different stages of erythropoiesis

GHK has a higher affinity for Cu than serum albumin does, so it effectively pulls copper off albumin and hands it to cellular copper chaperones and cuproenzymes lysyl oxidase, superoxide dismutase, cytochrome c oxidase that run ECM crosslinking, redox defense, and mitochondrial respiration