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What NAPQI does: Directly binds to and damages cellular proteins Depletes glutathione rapidly Generates oxidative stress which damages DNA Triggers cell death Damages mitochondria, disrupting energy production NAPQI crosses the placenta and depletes fetal brain glutathione at doses below those causing maternal liver toxicity

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doi: 10.1038/ncb0502-e127 99 SinghVRamMKumarRPrasadRRoyBKSinghKK