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Ozempic rose from a 10 th place ranking among the 10 top-selling Part D drugs in 2021, with gross spending of $2.6 billion, to 6 th place in 2022, with spending of $4.6 billion (Figure 2)

Additionally, GLP-1R expression in the nucleus ACBs may also contribute to this satiety function, more directly in the context of food-seeking motivated behaviors and reward signaling [56]