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Data availability All data included in this study are available upon request, sent to the corresponding author

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Donepezil, an acetylcholinesterase inhibitor, has shown promising results in mitigating cardiotoxicity induced by chemotherapeutic agents like doxorubicin and trastuzumab

Its defining scientific characteristic, selective stimulation of lipolysis through the beta-3 adrenergic receptor pathway without IGF-1 elevation or growth hormone receptor binding, is identical between both formats

The liver then converts the GH signal to IGF-1 over 8 to 24 hours, but that conversion is blunted in proportion to hepatocellular mass loss, as documented in cirrhosis research published in the Journal of Clinical Endocrinology and Metabolism

[DOI] [PubMed] [Google Scholar] 53.Ziegler O., Sirveaux M.A., Brunaud L., Reibel N., Quilliot D