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One of the limitations of our study is that we measured expression levels on transcriptional level only and the activity and quantity of the studied enzymes was not evaluated.

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Research shows that GLP-1 agonists like semaglutide activate receptor sites throughout the brain and pancreas, triggering cascades that stabilize leptin signaling, dampen cortisol stress responses, and restore insulin sensitivity in people with metabolic dysfunction

This paper reviews the structural and functional characteristics of GLP-1R