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once again, the dosage must be important, but additional genetic or acquired factors affecting the metabolism of the drug may play a role

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In our present paper we observed similar beneficial effects of L-arginine administration, because its addition to L-NNA, an inhibitor of NOS, before PTX restored the protective and hyperemic effects of PTX against WRS damage

"Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians"