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All the rest are water-soluble

Most native proteins have marginally stable folding patterns, and the accumulation of misfolded proteins can disrupt intracellular protein homeostasis networks, thereby inducing various diseases [13]

Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics comparison with orlistat (Xenical) Obesity (Silver Spring) 2010;18(1 ): 10815