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Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)

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Importantly, outcomes of various studies are not consistent which provides rationale for a meta-analysis of the relevant studies

Common Concerns After GLP-1 Weight Loss Rapid weight loss can reduce fat volume and skin elasticity faster than the body can adapt, leading to concerns such as: Facial hollowing or a tired, aged appearance (Ozempic face) Loose or sagging skin of the face, neck, arms, abdomen, or thighs Deflated breasts or changes in breast shape Loss of body contour and definition Crepey or lax skin texture Our approach focuses on restoring volume, tightening skin, and refining contours, while maintaining natural, balanced results

In Phase 2 trials, participants began on a low dose and were gradually escalated over several weeks to higher maintenance doses, up to 12 mg weekly

Despite their effectiveness, GLP-1 therapies are not without limitations