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The aim of the current exploratory analyses was to investigate whether different combinations of background medications and insulin regimens affected the efficacy and safety of oral semaglutide compared with active comparators and placebo in the PIONEER 3, 4, 5, 7 and 8 trials

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JAMA 2021;325:2262-72.PubMed 195

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Their clinical impact has since expanded dramatically due to their ability to induce sustained weight loss, improve insulin sensitivity, reduce systemic inflammation, and alter gut physiology

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