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In an observational study of patients denied TKA because of an institutional BMI cutoff, only 19.1% reached a BMI below 40 kg/m 2 within 2 years in the absence of dedicated weight-loss protocols, whereas 53.1% neither underwent TKA nor became eligible during follow-up ( 3 Why anti-obesity pharmacotherapy may change the logic of KOA care Modern anti-obesity pharmacotherapy may change the management of obesity-related KOA by making clinically meaningful weight reduction more achievable for selected patients

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American Family Physician (2016)

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Individual variation in drug response is significantbiological differences in GLP-1 receptor expression and function may contribute to why some patients naturally respond more robustly than others, though this is not routinely assessed in clinical practice