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Patients with non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD) with concurrent diabetes or obesity might benefit from the hepatic anti-inflammatory effects observed in clinical studies, though GLP-1 receptor agonists are not yet FDA-approved specifically for liver disease

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Semaglutide treatment effectively prevented the worsening of diastolic dysfunction, as evidenced by a reduced E/e ratio, and significantly decreased LVEDP by approximately 60% and reduced interstitial fibrosis ( Figure 1D-1E )

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