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In addition to improvements in glycemia and weight, the treatment effects include improvement in traditional cardiovascular risk factors associated with the cardiovascular benefit and, in some cases, improvement in novel cardiovascular risk factors [9]

Moreover, some environmental and lifestyle factors, such as poor nutrition, stress, alcohol consumption, smoking, and continuous exposure to UV radiation and pollution, also reduce glutathione reserves in our bodies

However, hypoglycemia can become a serious risk if GLP-1s are taken with medications that lower blood glucose, such as sulfonylureas or insulin

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Therefore, in PD Nrf2 activation and BBB preservation may cooperate to fight oxidative and inflammatory stressors [55]

(2020) 5:e138274