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They wrote: "It is noteworthy that the natural history of mitral valve regurgitation and the RAAS in Cavalier King Charles Spaniels are different from those of other breeds"

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b , Pull-down assay showing the interaction of GST-MpRALF1 (left), GST-MpRALF1 N18 (middle) or GST-MpRALF1 C38 (right) with MBP-MpFERecd or MBP-MpFERecd G282A