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NAD+ Repletion Rescues Female Fertility during Reproductive Aging

These molecules integrate hormonal signals with intracellular energy and lipid status, ultimately influencing gene expression through transcriptional and epigenetic mechanisms

The loss of Opa1 also results in increased mtDNA damage and ROS production, further exacerbating T cell exhaustion [149]

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3.3.2 Ferroptosis and Endoplasmic Reticulum Stress Ferroptosis can also participate in myocardial I/R injury by modulating ERS (Wang et al., 2019), and ferroptosis can also lead to ERS via cystine-glutamate antiporter System X c (Sun et al., 2015)