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Perhaps, these findings are explained by the well-established acute nature of APAP-induced hepatotoxicity and elevated tolerance of female mice

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10.1007/s00213-011-2354-9 Psychopharmacology 125 LocascioA.AnnonaG.CaccavaleF.DAnielloS.AgnisolaC.PalumboA

Critically, these effects were absent in 3-AR knockout mice, indicating that an intact 3-AR pathway is required for the lipolytic activity