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Metanx was administered to 15 week old ZDF and ZDF lean rats at either 4.87 mgkg -1d -1 (the dose used in clinical practice) or 24.35 mgkg -1d -1, 2 times a day, for 4 weeks

Mol Microbiol 39(3):533541 Kieliszek M, Baejak S, Piwowarek K, Brzezicka K (2018) Equilibrium modeling of selenium binding from aqueous solutions by Candida utilis ATCC 9950 yeasts

Notably, while the increase in amniotic fluid CSE levels did not reach statistical significance, maternal serum CSE levels were significantly higher in Down syndrome cases compared to controls, with an approximately twofold increase

95% confidence interval [CI]: 0.41 to 0.97)