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The effect is dose-dependent and peaks when exercise duration exceeds 30 minutes, the threshold where intramuscular triglyceride stores deplete and circulating FFAs become the primary fuel source

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The trials demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo

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For Caucasians, ADH1B*1 allele is the most prevalent allele which causes slower conversion of alcohol to acetaldehyde and it makes them more vulnerable to alcohol use disorders

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