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f) 15 nM BG-ASO and 85 nM control ASO over 15 nM BG-ASO and 35 nM control ASO

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Collectively, NOXs and the ETC generate roughly 85% of H 2 O 2 , with the remaining production deriving from oxidases in the endoplasmic reticulum (ER) and peroxisomes, as well as from cumulative environmental stressors such as UV or ionising radiation 8,40,42,43

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GHK-Cu affects over 4,000 human genes, upregulating pathways associated with tissue maintenance and downregulating inflammatory and degenerative cascades