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Genetic susceptibility and overnutrition states, i.e., chronic hyperglycemia and hyperlipidemia, are the causes of insulin resistance and low-grade chronic inflammation

DJH and BRR receive financial support from the Australian Research Council Linkage Projects scheme (LP140100095)

How Dihexa Works (Proposed and Partly Retracted) The proposed mechanism is that Dihexa potentiates hepatocyte growth factor (HGF) signaling at the c-Met (MET) receptor, downstream of PI3K-AKT, driving dendritic spine formation and synaptogenesis

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