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Researching an off-ramp Clinicians have a body of research on starting GLP-1s, but theres less evidence on how to stop them, Biermann says

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Specific amino acid substitutions and a C18 fatty-acid side chain enhance albumin binding, reduce renal elimination, and confer resistance to DPP-4 degradation, extending its half-life to approximately one week and enabling once-weekly administration [14]

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