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The anti-inflammatory mechanism of SGLT2i is also related to the HIF signaling pathway, activated AMPK signaling pathway and mitochondrial energy metabolism (162)

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The monolayer experiments performed in this study indicate that AOM does not cause increased endothelial cell permeability directly, but that TGF 1 contributes to increased monolayer permeability in this model

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van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, et al