At week 72, the clinical data showed that 36.8% of patients receiving semaglutide achieved fibrosis improvement without worsening of NASH and 62.9% achieved NASH resolution without worsening of fibrosis, compared with 22.4% and 34.3%, respectively, in the placebo group (Sanyal et al., 2025)
However, because weight loss can change your thyroid hormone requirements, it is essential to monitor your levels closely with your GP, as your dose of levothyroxine may need to be adjusted over time
Side Effects to Be Aware of When Beginning Treatment The most common side effects during retatrutide initiation are gastrointestinal, particularly nausea, and are generally dose-dependent and transient
Consult the FDA and a licensed healthcare professional for current regulations and individualized guidance.
Hankosky ER, Wang H, Neff LM, Kan H, Wang F, Ahmad NN, Griffin R, Stefanski A, Garvey WT
Published: Aug 7, 2025 Written by Klarity Editorial Team Published: Aug 7, 2025 Starting a GLP-1 medication like semaglutide (Ozempic or Wegovy) comes with certain expectations, particularly around appetite suppression
