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This sustained occupancy is what drives the consistent A1C and weight reductions seen in long-duration SURPASS trials rather than a pulse-and-wane effect

It involves a period of trial and adjustment

Recently, a registry-based case-control study of 1,961 patients also associated the use of GLP-1R agonists with a reduced risk of glaucoma (Sterling et al., 2021), strongly supporting further research into the use of agents that increase GLP-1R signaling as anti-glaucomatous treatment strategies

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10.3748/wjg.v30.i30.3541 79 StrowskiM

So the case becomes less about any one GLP-1 drug and more about who has the authority to balance access against affordability