The New Pharmaceutical Imperative With strong evidence suggesting systemic benefits far beyond glycemic control and weight managementincluding cardiovascular protection and effects on inflammationGLP-1s are now viewed as foundational longevity therapeutics
*Correspondence: Xian-Feng Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
For instance, Liraglutide, popularly known as Victoza or Saxenda, has been approved specifically for weight loss by the FDA
519 Ultimately, GLP-1RA, by regulating BMP4 and its effects on cell proliferation and metastasis, provides a promising treatment approach
Gastrointestinal side effects, including nausea, vomiting, and diarrhea, are extremely common with GLP-1 therapy and may exacerbate nutritional deficits while directly contributing to feelings of unwellness and fatigue
Combination and Small Molecule GLP-1 Drugs The number of main pipelines is even smaller for small-molecule GLP-1 drugs and GLP-1 combination drugs