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In addition, the rise of e-commerce platforms, the emergence of virtual galleries and museums, and the proliferation of online education platforms have transformed traditional experiences, replacing physical activities with digital ones

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480,481,482,483 The role of the UPS in autoimmune diseases The UPS regulates processes relevant to autoimmune diseases, such as antigen presentation, cytokine production, T-cell receptor signaling, and inflammasome activation, making it a central player in immune homeostasis and inflammation